Sunday, April 14, 2013

Jumpvine.com - Website for Sale on Flippa: PPC Advertising ...

Own Your Own Ad Network!

Jumpvine.com - PPC Advertising Network

Jumpvine is a powerful, feature rich, fully customizable PayPerClick advertiser/publisher network. Advertisers can register with the adserver and? post their text/banner/catalog PayPerClick (PPC) ads. Publishers can create ad display units and?use it in their websites to show ads relevant to their page content. You can completely control your revenue from the system by adjusting the minimum click bid value as well as the percentage of click bids you would share with publishers. The system comes with support for load balancing across multiple servers which means you never need to worry about performance bottlenecks. The entire system is template driven which allows you to easily modify the advertiser, publisher pages to your preference. Also the system comes in 14 languages and you can add more.

Manage Publishers

Jumpvine.com?allows you to manage your publishers effectively than ever.?You can review each publisher account before approving the same. The system allows you to to specify the click bid percentage to be shared with publishers. You can get details about his click and profit statistics, fraud statistics and withdrawal history anytime. The robust and improved fraud control measures allows you to monitor,?warn and block suspicious publishers.

Manage Advertisers

Now using?Jumpvine.com you can manage your advertisers in a better way. You can review their ads and if you find their ads? inappropriate for your terms, you may block their accounts. You can check the complete profile of an advertiser which contains information about ads posted by the advertiser, click statistics of the advertiser and payment history. Also you have the option for adding fund to advertiser's bonus/account balance.

Is Jumpvine your future?

Jumpvine.com is a custom designed advertising network similar to that of google adsense and adwords. It is basically your very own advertising network. Jumpvine uses?a very sophisticated advertising platform in the backend,

Just a few years ago starting your own ad network wasn?t easy nor within reach for the regular person and the capital needed was huge!

Jumpvine has everything you need to run your own ad network and start selling traffic.

Why would you want to start your own ad network?

Because there is a lot of money being made in selling media. Any affiliate or business that has a product to sell online needs traffic. Traffic is the lifeblood of any business.

Advertising is one of the few industries that just keeps growing each year. More and more companies spend money on online advertising and there is no limit to how much money you can make.

Jumpvine?is very simple and easy to run even for a beginner,?doesn't require any exerience or maintenance. Jumpvine is perfect for?anyone including webmasters who are looking to?advertise?their brand, develop traffic to their sites and acquire?more customers. With millions of existing websites and new websites?being created every day, you will have no shortage of customers who want?to buy the services offered by Jumpvine.com - The new kid on the block!

Selling traffic is a very scalable business model and very sustainable.

- Full control of your ad network. You can approve, suspend and terminate accounts.

Jumpvine is a great investment for those that own several websites. With skyrocketing cost of advertising on Google and Bing. With the right person at the helm Jumpvine has the potential to give either of them a run for their money and save the owner a ton of money.

What's Included

Jumpvine.com domain and custom designed ad network website.

Why?am I?selling?

At the moment I am involved in non-internet project that will consume most of my time.

?Jumpvine is a beautiful site that?is capable of making?a hansom monthly revenue and growing in value.

Currently the site makes no revenue as it has not been advertised. I was nearing the end of development of the site when?my?non-internet project starting taking off.?

This will be a 10-day auction with the ad network going to the highest bidder once the reserve has been met.?

Happy Bidding!

To express your interest to the seller, or post a public comment, you need to log in or sign up.

Source: https://flippa.com/2886942-ppc-advertising-network-for-sale-own-your-own-ad-network

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Saturday, April 13, 2013

Snedeker, Cabrera tied for lead at Masters

AUGUSTA, Ga. (AP) ? Tiger Woods made two significant moves Saturday at the Masters ? one to stay in the tournament, the other to stay in the hunt.

A day filled with high drama before a shot was struck at Augusta National, ended with Brandt Snedeker and Angel Cabrera tied for the lead, and Woods only four shots back. For a few tense hours in the morning, it was not clear if Woods was going to get a chance to play.

Masters officials discovered late Friday evening that Woods had taken a bad drop in the second round and should have added two shots to his score.

Under normal circumstances, he would have been disqualified for signing an incorrect card. Officials took the blame for not alerting Woods to a potential problem ? they found nothing wrong at first glance before he signed ? and kept him in the tournament with two shots added to his score. Woods was covered under a 2-year-old rule that prevents DQs when a violation is reported by television viewers.

"It certainly was a distraction early," Woods said after three birdies on his last seven holes for a 70. "It happens and you move on. I was ready to play come game time."

So was Snedeker.

He's been building toward a moment like this for the last year, and he seized his chance on a glorious afternoon with a bogey-free round of 3-under 69. After opening with 12 pars, he birdied both the par 5s and stuffed his tee shot to 4 feet for birdie on the par-3 16th to take the lead. Cabrera joined him at 7-under 209 with a 12-foot birdie putt on the final hole, capping off a round in which he twice made bogey on the par 5s.

They were two players going in opposite directions this year. Snedeker was seen as the hottest player in golf when in three straight weeks he was runner-up to Woods, runner-up to Phil Mickelson and then won at Pebble Beach. His momentum was slowed by sore ribs that kept him out of golf for a month, though he appears to be hitting his stride.

"I've spent 32 years of my life getting ready for tomorrow," Snedeker said. "I'm going to be disappointed if I don't win. Period. I'm not here to get a good finish. ... I'm here to win."

Cabrera, whose two major titles include a Masters win in 2009, has plunged to No. 269 in the world.

"I've been working very hard for this moment," Cabrera said through an interpreter. "And I've got to take the opportunity."

For Adam Scott, it's a chance at redemption.

He was runner-up at the Masters two years ago, though the fresher wounds are from last summer at Royal Lytham & St. Annes, where the Australian bogeyed his last four holes and finished one shot behind in the British Open. Scott rammed home a 25-foot birdie putt on the 17th hole for a 69 and was one shot behind.

Two more Aussies, Marc Leishman (72) and Jason Day (73) were another shot behind, giving the blokes from Down Under as good a chance as ever to give their country some happy memories from Augusta National. It's the only major an Australian has never won, a point driven home with every mention of Greg Norman losing a six-shot lead on the last day in 1996.

"Obviously, to win the Masters would be incredible," Scott said. "It would be great for Australia. We've never looked better odds-wise going into a Sunday, except that one year in 1996. It's going to be a hell of a round tomorrow."

Day was in the lead for most of the day, going 18 straight holes without a bogey until he missed short par putts on the last two holes.

Matt Kuchar (69) was three shots back, and Woods was right behind.

Woods, the No. 1 player in the world who already has won three times this year, was the heavy favorite going into the Masters to capture a green jacket for the first time since 2005 and end his five-year drought in the majors.

His big move came after a bogey on the 11th hole, leaving him six shots behind as he made his way through a back nine that has not treated him kindly of late. But he ran off three birdies on the next four holes, and made clutch par saves on the 16th and 18th to stay in the game.

"I'm right there in the ball game, "Woods said. "I'm four back with a great shot to win this championship."

History is not on his side. Woods has never won a major from behind, every Masters champion has been no worse than a tie for fourth going into Sunday dating to Faldo's comeback in 1989. But at least he's still in the game.

That was never in doubt to the officials running the Masters. Fred Ridley, chairman of the competition committees, said he looked at video as Woods was playing the 18th hole Friday and saw no need to ask him about the drop because he didn't detect a violation. It was only after Woods' post-round interview when he implicated himself by saying he went back a few yards by design that it became an issue.

Because he saw no problem at first with the drop and let Woods sign his card without talking to him, Ridley said it would have been "grossly unfair to Tiger to have disqualified him." He said the notion of a DQ was "not even on the table."

Woods couldn't have been too shaken up by the morning activities. He birdied the first hole. The key for everyone was simply to stay somewhere around contention, and that wasn't easy. Rory McIlroy was only three shots out of the lead when he took a bogey on the seventh hole. Little did Boy Wonder realize that it would start a nasty cycle. With a pair of 7s on his card on the back nine ? wind shifts led to a triple bogey on the 11th and a double bogey on the 15th ? he shot 42 on the back for a 79.

"I play 7 through 11 in 5-over par and basically my chances in the tournament are gone," McIlroy said. "So it's very disappointing. I feel like I have been playing well coming in here and it's just a frustrating day here."

Former PGA champion Keegan Bradley had an 82, while Mickelson shot 40 on the back nine for the second straight day and had a 77. Guan Tianlang, the 14-year-old from China, went his second straight round without a birdie and had a 77. He was still smiling, soaking in his weekend at Augusta as the youngest player to make a cut in a PGA Tour-sanctioned tournament.

Meanwhile, Snedeker takes an amazing streak into the final round. He has gone 27 consecutive holes without a bogey at Augusta National, and he has a clear plan of what he needs to do be fitted for a green jacket.

"If I drive the ball in the fairway and play the par 5s well tomorrow, I'm going to have a really good day."

Source: http://news.yahoo.com/snedeker-cabrera-tied-lead-masters-232455720--spt.html

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Enzymes from horse feces could hold secrets to streamlining biofuel production

Apr. 11, 2013 ? Stepping into unexplored territory in efforts to use corn stalks, grass and other non-food plants to make biofuels, scientists have described the discovery of a potential treasure-trove of candidate enzymes in fungi thriving in the feces and intestinal tracts of horses.

They reported on these enzymes -- the key to economical production of biofuels from non-food plant material -- at the 245th National Meeting & Exposition of the American Chemical Society (ACS) currently going on in New Orleans.

Michelle A. O'Malley, Ph.D., explained that cellulose is the raw material for making biofuels from non-food plant materials. Cellulose, however, is sealed away inside a tough network of lignin within the cell walls of plants. To produce biofuels from these materials, lignin must be removed through an expensive pretreatment process. Then, a collection of enzymes breaks cellulose down into sugars. Finally, in a process much like production of beer or wine, those sugars become food for microbes to ferment into alcohol for fuel, ingredients for plastics and other materials.

"Nature has made it very difficult and expensive to access the cellulose in plants. Additionally, we need to find the best enzyme mixture to convert that cellulose into sugar," O'Malley said. "We have discovered a fungus from the digestive tract of a horse that addresses both issues -- it thrives on lignin-rich plants and converts these materials into sugars for the animal. It is a potential treasure trove of enzymes for solving this problem and reducing the cost of biofuels."

The digestive tracts of large herbivores like cows and horses, which can digest lignin-rich grasses, have been a well-trodden path for scientists seeking such enzymes. But in the past, their focus has been mainly on enzymes in bacteria, rather than fungi, which include yeasts and molds. The goal: Take the genes that produce such enzymes from gut fungi and genetically engineer them into yeasts. Yeasts already are used in time-tested processes on an industrial scale to produce huge quantities of antibiotics, foods and other products. That proven production technology would mean clear sailing for commercial production of biofuels.

O'Malley explained that several genes from gut fungi are unique compared to bacteria, since the fungi grow invasively into plant material. Also, they secrete powerful enzyme complexes that work together to break down cellulose. Until now, however, fungi have largely been ignored in the search for new biofuel enzymes -- and for good reason.

"There was relatively little scientific knowledge about fungi in the digestive tracts of these large animals," O'Malley explained. "They are there, but in very low numbers, making it difficult to study. The low concentrations also fostered a misconception that fungi must be unimportant in digestion of cellulose. And it is extremely difficult to isolate and grow these fungi to study their enzymes."

O'Malley's research group at the University of California, Santa Barbara, collaborated with researchers at the Broad Institute of the Massachusetts Institute of Technology and Harvard University. They worked with a gut fungus isolated from horse feces and identified all the genetic material that the fungus uses to manufacture enzymes and other proteins. This collection of protein-encoding material -- the fungus's so-called "transcriptome" -- led to the identification of literally hundreds of enzymes capable of breaking through that tough lignin in plant cell walls and the cellulose within. The team now is shifting through that bounty to identify the most active enzyme and working on methods for transferring the genetic machinery for its production into the yeast currently used in industrial processes.

The scientists acknowledged support from the United States Department of Agriculture, The Institute for Collaborative Biotechnologies through contract no. W911NF-09-D-0001 from the U.S. Army Research Office and the University of California, Santa Barbara.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/vzDX5ot7N6g/130411194641.htm

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U.S. says N. Korea test would be "big mistake"

By Arshad Mohammed and Jack Kim

SEOUL (Reuters) - U.S. Secretary of State John Kerry warned North Korea on Friday it would be a "huge mistake" to test launch a medium-range missile and said the United States would never accept the reclusive country as a nuclear power.

Addressing reporters after talks with South Korea's president and leaders of the 28,000-strong U.S. military contingent in the country, Kerry also said it was up to China, North Korea's sole major ally, to "put some teeth" into efforts to press Pyongyang to abandon its nuclear ambitions.

Kerry, like other U.S. officials, played down an assessment from the Pentagon's intelligence agency that the North already had a nuclear missile capacity.

The United States, he said, wanted to resume talks about North Korea's earlier pledges to halt its nuclear programme.

But he also stressed that Washington would defend its allies in the region if necessary and pointedly said that Kim Jong-un, the North Korean leader, "needs to understand, as I think he probably does, what the outcome of a conflict would be".

North Korea has repeatedly said it will not abandon nuclear weapons which it said on Friday were its "treasured" guarantor of security.

Kerry's visit coincided with preparations for Monday's anniversary of North Korean state founder Kim Il-Sung's birth date, a possible pretext for a show of strength, with speculation focusing on a possible new missile test launch.

GRAPHIC: N.Korea's military http://link.reuters.com/zur27t

GRAPHIC: Korea's economic divide http://r.reuters.com/gyn84t

Kerry, who flies to China on Saturday and to Japan on Sunday, said that if North Korea's 30-year-old leader went ahead with the launch, "he will be choosing, wilfully, to ignore the entire international community".

"I would say ahead of time that it is a huge mistake for him to choose to do that because it will further isolate his country and further isolate his people, who frankly are desperate for food, not missile launches."

SHRILL RHETORIC

The North has issued weeks of shrill threats of an impending war following the imposition of U.N. sanctions in response to its third nuclear test in February. Kerry said the threats were "simply unacceptable" by any standard.

"We are all united in the fact that North Korea will not be accepted as a nuclear power," he said.

Kerry later told U.S. executives in Seoul that China, as an advocate of denuclearisation, was in a position to press for a change in the North's policy.

"The reality is that if your policy is denuclearisation and it is theirs as it is ours, as it is everybody's except the North at this moment ... if that's your policy, you've got to put some teeth into it," he told the gathering.

But North Korea showed little inclination for further talks.

Rodong Sinmun, the mouthpiece of the ruling Workers' Party, said Pyongyang would never abandon its nuclear programme.

"The DPRK will hold tighter the treasured sword, nuclear weapons," it said, referring to the country by its official name, the Democratic People's Republic of Korea.

BIRTHDAY CELEBRATIONS

North Korean state television showed footage of newscasts from other countries depicting the trajectory a North Korean missile launch might take.

It also showed preparations for the Kim Il-Sung birthday festivities, including floral tributes, and a stadium of thousands of school children of the Korean Children's Union, each wearing a red scarf and saluting and marching in unison.

Speculation has mounted of an impending medium-range missile test launch in the North after reports in South Korea and the United States that as many as five medium-range missiles have been moved into position on the country's east coast.

Officials in both countries believe the North is preparing to test-launch a Musudan missile, whose range of 3,500 km (2,100 miles) or more would put Japan within striking distance and may threaten the island of Guam, which houses U.S. military bases.

The North has been angry about annual military drills between U.S. and South Korean forces, describing them as a "hostile" act. The United States dispatched B52 and B2 stealth bombers from their bases to take part.

Hours before Kerry's arrival, a U.S. lawmaker quoted a report by the U.S. Defence Intelligence Agency, one of the 17 bodies that make up the U.S. intelligence community, as saying it had "moderate confidence" that North Korea had developed a nuclear bomb that could be fitted on a ballistic missile.

But Kerry poured cold water on the report said it was "inaccurate to suggest that the DPRK has fully tested, developed capabilities" as set down in the document.

South Korea's Defence Ministry said it did not believe North Korea could mount a nuclear warhead on a missile.

A U.S. official had earlier suggested that Washington's greatest concern was the possibility of unexpected developments linked to Kim Jong-un's "youth and inexperience". Asked if war seemed imminent, he replied: "Not at all."

South Korean President Park Geun-hye, meeting officials from her ruling Saenuri Party before her talks with Kerry, struck a conciliatory note by suggesting Seoul should at least listen to what North Korea had to say.

"We have a lot of issues, including the Kaesong industrial zone," local media quoted her as saying. So should we not meet with them and ask: "Just what are you trying to do?'"

The president was referring to North Korea's closure this week of the jointly run Kaesong industrial park, with the loss of 53,000 jobs.

Kerry said the United States would not object to the South talking to the North. He also did not rule out the possibility of U.S. aid some day flowing to the North, but suggested this could only happen if Pyongyang undertook real denuclearisation.

Kerry sounded upbeat about resolving a dispute between the United States and South Korea over a civil nuclear cooperation agreement that expires next year, saying he thought a compromise could be found by Park's visit to Washington next month.

South Korea is believed to want the right to reprocess its spent nuclear fuel, which would allow it to deal with a mounting stockpile of nuclear waste.

However, this could also allow it to produce bomb-grade fissile material, a step Washington is loathe to see it take in part because of its nuclear standoffs with Iran and North Korea.

"We are ... very concerned at this time about not having any ingredients that could alter our approach ... to either of those," he said. But Kerry added that he was "confident that one option or another will be able to come to fruition (with South Korea) by the time that President Park comes to Washington." (Additional reporting by Ju-min Park in SEOUL, Sui-Lee Wee in BEIJING, John Ruwitch in SHANGHAI, and Patricia Zengerle, Mark Hosenball and Jeff Mason in WASHINGTON; Writing by Ronald Popeski and Arshad Mohammed; Editing by Nick Macfie and Jon Hemming)

Source: http://news.yahoo.com/u-never-accept-nuclear-armed-north-korea-kerry-110014598.html

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Wednesday, March 6, 2013

Ferrari outs 949HP LaFerrari hybrid, gives FF drivers iPad minis and Siri (video)

The LaFerrari unveiled at Geneva

Maranello, 5th March 2013 ? The wraps are finally off the LaFerrari. The Prancing Horse's eagerly-anticipated limited-series special, of which just 499 will be built, made its world debut today at the Geneva International Motor Show.

"We chose to call this model LaFerrari," declared Ferrari's President, Luca di Montezemolo, "because it is the maximum expression of what defines our company ? excellence. Excellence in terms of technological innovation, performance, visionary styling and the sheer thrill of driving. Aimed at our collectors, this is a truly extraordinary car which encompasses advanced solutions that, in the future, will find their way onto the rest of the range, and it represents the benchmark for the entire automotive industry. LaFerrari is the finest expression of our company's unique, unparalleled engineering and design know-how, including that acquired in Formula 1."

For Ferrari the development of a limited-series special like the LaFerrari represents an opportunity to experiment with all the technological solutions that will later filter down onto the production cars. Of particular significance in this context is the introduction of the hybrid system which, making full use of the Scuderia Ferrari's F1 KERS know-how, has resulted in a solution that exalts Ferrari's fundamental values ? performance and driving thrills. The hybrid technology used, known as HY-KERS, represents the perfect combination of maximum performance and lower emissions. LaFerrari in fact emits just 330 g/km of CO2 but without resorting to electric-only drive which would not fit the mission of this model. The HY-KERS system is, however, designed so that in future applications a car can be driven using exclusively electric power for a few kilometres and, during development testing, a full-electric version of LaFerrari achieved just 220 g/km of C02 emissions on the combined cycle.

The LaFerrari is equipped with dynamic controls that are integrated for the first time ever on a Ferrari road car with active aerodynamics and the HY-KERS system. Thanks to Ferrari's proprietary logic which govern all the systems, the car can achieve absolute levels of performance, aerodynamic efficiency and handling without any form of compromise in any area. A very advanced and uncompromising approach was also taken with the interior design which features an HMI inspired by F1 single-seaters.

Architecture

The LaFerrari's architecture posed the first challenge for the Prancing Horse team at the planning stage of the design. The aim was to achieve ideal weight distribution (59% at the rear) and a compact wheelbase despite the extra bulk of the hybrid system. The result is that all of the masses are situated between the car's two axles and as close as possible to the floor to lower its centre of gravity (by 35 millimetres) and thereby guarantee dynamic handling and compact dimensions.

The layout of the cabin made a significant contribution in this regard. The seat is fixed and tailored to the driver while both the pedal box and steering wheel are adjustable. The driving position is similar to that of a single-seater and was designed after consultation with the Scuderia Ferrari drivers, Fernando Alonso and Felipe Massa, who played an active role throughout the entire development process.

The LaFerrari's chassis features no less than four different types of carbon-fibre, all hand-laminated and autoclave-cured in the racing department using the same design and production methods as the Formula 1 car. This helped optimise the design: various functions were integrated (e.g. seats and battery compartment) into the chassis to improve torsional rigidity (+27%) and beam stiffness (+22%) whilst cutting weight.

Powertrain

The LaFerrari is the first car in Ferrari history to be powered by the HY-KERS system. The ICE represents the pinnacle of engine development and research, with a 6262 cc V12 that punches out 800 CV and revs to a maximum of 9,250 rpm, a record for an engine of this displacement. It also features a very high 13.5:1 compression ratio and a high specific output equal to 128 CV per litre. The engine is coupled with a 120 Kw (163 CV) electric motor, giving it a combined power output of 963 CV.

The high torque levels available at low revs from the electric motor allowed the engineers to optimise the internal combustion engine's performance at higher revs, thus providing a constant supply of exceptional power throughout the rev range. Total torque generated is in excess of 900 Nm. The hybrid system is composed of two electric motors developed in collaboration with Magneti Marelli ? one powering the driven wheels and the second the ancillaries ? and a battery pack attached to the floor of the chassis consisting of cells that are assembled in the Scuderia Ferrari department where the KERS for the F138 is also made. The Scuderia's expertise allowed considerable savings in weight and size of the individual components and the batteries weigh just 60 kg while providing the highest energy density possible for this kind of application.

The batteries are charged in different ways: under braking (even hard braking with the ABS active) and every time the V12 produces more torque than required, such as in cornering. In the latter instance, rather than the being sent to the wheels, the excess torque is converted to energy and stored in the batteries.

The electric motor is coupled with the F1 dual-clutch gearbox to the benefit of optimal weight distribution, but also to boosting energy efficiency as torque is instantly available to the wheels and, vice versa, from the wheels to the electric motor in recharging.

Aerodynamics

Active aerodynamics play an essential role, as they allow a complete adjustability of the car's configuration to attain LaFerrari's exceptional performance.

The engineers' aim was to deliver the highest degree of aerodynamic efficiency ever achieved with any road car, with a coefficient of nearly 3, thanks to technical solutions honed with CFD analysis and fine-tuned in the F1 Wind Tunnel.

To boost efficiency, the LaFerrari sports active aerodynamic devices front (diffusers and guide vane on the underbody) and rear (diffusers and rear spoiler) which generate downforce when needed without compromising the car's overall drag coefficient. These devices deploy automatically on the basis of a number of different performance parameters which are monitored in real time by the car's dynamic vehicle controls, thus guaranteeing the ideal configuration on the basis of the driving conditions.

Control systems

One further innovative aspect of the LaFerrari is the integration of its active aerodynamics and hybrid system with the other dynamic control systems aboard. This means the car responds intelligently to driver inputs, making for a seamless blend of unprecedented performance and unparalleled driving emotions.

Proprietary Ferrari algorithms deliver optimal integration of the electric motor and V12 for instantaneous response. In cornering, for instance, the HY-KERS keeps the V12's revs high to guarantee better acceleration on exit.

The LaFerrari's Brembo braking system is also integrated with the hybrid system, and incorporates several new features, including new lightweight callipers designed to guarantee correct cooling and carbon-ceramic material (CCM) discs featuring a new composition.
The car's extreme performance potential called for a different tyre set-up, with 265/30 R 19 Pirelli P-Zeros on the front and 345/30 R 20s on the rear.

All in all the car guarantees maximum driving thrills in every situation and performance levels are top level: 0-100 km/h in less than 3 seconds and 0-200 km/h in under 7 seconds, a lap time at Fiorano of under 1'20" ? 5 seconds faster than the Enzo and over 3 seconds faster than the F12berlinetta. LaFerrari is thus the fastest road car in Maranello's long history.

Styling The Ferrari design team led by Flavio Manzoni developed the LaFerrari's styling working in close synergy with the engineers to emphasise the exacting link between form and function. The result is an extreme, innovative design which retains close links to the marque's tradition. This is most evident in its side profile: the car has a sharp, downward-sloping nose and a very low bonnet which emphasises its muscular wheelarches, a clear nod to the gloriously exuberant forms of late-1960s Ferrari sports prototypes.

The LaFerrari's body has been given a sculptural treatment heavily influenced by its clearly F1-inspired aerodynamics and a tail section that exudes uncompromising sportiness.
Inside there's a newly-designed steering wheel sporting all the major commands, and the gear-shift paddles are now longer and more ergonomic. The signature bridge on which the F1 gearbox functions are clustered has taken on a sleek, suspended wing-like shape. The whole interior, in fact, has a fiercely track-inspired, pared-back allure.

The Ferrari range

Aside from the new limited-series special, the Ferrari stand also features the complete range which is the most wide-ranging and critically acclaimed in its entire history. The five models all share the same Ferrari DNA in terms of performance, driving pleasure and technology, yet each one has its own strongly unique identity, in line with the company's philosophy of "different Ferraris for different Ferraristi".

Ferrari's 12-cylinder GT sports car prowess is represented at Geneva by the FF, the very first four-seater and four-wheel drive in Prancing Horse history. It will be sporting a Grigio Ingrid livery with an elegant glass roof and Iroko interior. The FF is also now seamlessly integrated with Apple technologies, thanks to direct access to the infotainment system via SIRI voice commands and the adoption of two iPad Minis as the entertainment system of choice for the rear seat passengers.

Blistering performance and sublime driving pleasure even at low speeds are assured behind the wheel of the multi-award-winning F12berlinetta, which is powered by a mid-front V12. Unique handling characteristics, extreme aerodynamics and an innovative yet classic design are its signatures. The car on show at Geneva has a Grigio Silverstone livery and a Sella di Cavallo interior.

Moving on to the 8-cylinders, the California 30, in sophisticated Nero Stellato with a Crema interior, is a convertible GT that uncompromisingly marries sportiness and versatility. The California's already-massive popularity with both press and public alike grew still further after its V8's output was upped by 30 hp to 490 hp, and 30 kg was slashed off its overall weight.

The blistering 458 Italia is a sublime, thoroughbred sports car. It and its drop-top sibling, the 458 Spider, are equipped with the same extraordinary mid-rear-mounted V8 engine which was named International Engine of the Year in both 2011 and 2012. These two models continue Ferrari's glorious tradition with this particular layout. The coup? seen at Geneva sports an aggressive Bianco Avus livery and sleek black interior with carbon-fibre trim, while the Spider, which dominates the Tailor-Made extreme personalisation area, takes its inspiration from the legendary 1957 250 Testa Rossa that sold for a record 16 million dollars at auction at Pebble Beach in 2011. It has the same red and blue livery and a host of competition car details in its cabin, not least of which are suede-upholstered seats and Alutex trim.

Source: http://www.engadget.com/2013/03/05/ferrari-shows-949hp-laferrari-hybrid-gives-ff-drivers-ipad-mini/

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Tuesday, March 5, 2013

The right dose for oncology

The right dose for oncology [ Back to EurekAlert! ] Public release date: 4-Mar-2013
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Contact: Lionel Pousaz
lionel.pousaz@epfl.ch
41-795-597-161
Ecole Polytechnique Fdrale de Lausanne

King Mithridates understood that poison is only as good as the dosage taken. Each day, he ingested small quantities of poison in order to become immunize and escape his court's plotters. Oncologists run up against the same principle when fighting cancer. Sometimes, a small dose of chemotherapy may induce dangerous resistance mechanisms in malignant cells, resulting in relapse. Now, EPFL research published in the journal PLOS ONE reports a tool that could simply and accurately determine the right dose for individual patients.

Dosage, a vital issue

This novel tool, developed by Philippe Renaud's team at EPFL, is based on a very simple principle: a cell's electrical conductivity depends on the level of stress induced by chemotherapy. In broad terms, by measuring a cancerous cell's capacity to conduct electricity, researchers can assess the intensity of the treatment's effect.

"When chemotherapy induces very little stress in cells, particularly after the application of a small dose, there is a problem," says Robert Meissner, a co-author of the study. "Not only is its effect not sufficient to kill the affected cells, but this actually increases the risk of inducing resistance, which will eventually make the treatment ineffective."

This is vital during relapse as cells have already developed resistance mechanisms and sometimes oncologists don't have an effective alternative therapy. Hence, it is fundamental to apply the right dose from the start.

Step towards personalized oncology

The method developed at EPFL could help doctors make more patient-specific decisions. "We fully subscribe to the trend of personalized medicine," explains Philippe Renaud. "By making a simple biopsy, oncologists could test the way a particular patient's cells respond to different types of treatments at various doses."

The tool, which was designed for a clinical environment, provides a simple and fast analysis without affecting the treated cells. Unlike methods based on biomarkers, which kill cells and are extremely strenuous to perform, the EPFL technology could be implemented easily in a medical environment. In fact, scientists have already tested it on malignant breast cells treated with a standard drug, doxorubicin.

The EPFL team is currently in discussion with oncologists to continue jointly developing their procedure. Within a few months, researchers say, a startup company will likely be created to help bring the laboratory work into the hospital setting.

###

Researcher Contact:

Robert Meissner, EPFL
robert.meissner@epfl.ch
+ 41 216936752


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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The right dose for oncology [ Back to EurekAlert! ] Public release date: 4-Mar-2013
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Contact: Lionel Pousaz
lionel.pousaz@epfl.ch
41-795-597-161
Ecole Polytechnique Fdrale de Lausanne

King Mithridates understood that poison is only as good as the dosage taken. Each day, he ingested small quantities of poison in order to become immunize and escape his court's plotters. Oncologists run up against the same principle when fighting cancer. Sometimes, a small dose of chemotherapy may induce dangerous resistance mechanisms in malignant cells, resulting in relapse. Now, EPFL research published in the journal PLOS ONE reports a tool that could simply and accurately determine the right dose for individual patients.

Dosage, a vital issue

This novel tool, developed by Philippe Renaud's team at EPFL, is based on a very simple principle: a cell's electrical conductivity depends on the level of stress induced by chemotherapy. In broad terms, by measuring a cancerous cell's capacity to conduct electricity, researchers can assess the intensity of the treatment's effect.

"When chemotherapy induces very little stress in cells, particularly after the application of a small dose, there is a problem," says Robert Meissner, a co-author of the study. "Not only is its effect not sufficient to kill the affected cells, but this actually increases the risk of inducing resistance, which will eventually make the treatment ineffective."

This is vital during relapse as cells have already developed resistance mechanisms and sometimes oncologists don't have an effective alternative therapy. Hence, it is fundamental to apply the right dose from the start.

Step towards personalized oncology

The method developed at EPFL could help doctors make more patient-specific decisions. "We fully subscribe to the trend of personalized medicine," explains Philippe Renaud. "By making a simple biopsy, oncologists could test the way a particular patient's cells respond to different types of treatments at various doses."

The tool, which was designed for a clinical environment, provides a simple and fast analysis without affecting the treated cells. Unlike methods based on biomarkers, which kill cells and are extremely strenuous to perform, the EPFL technology could be implemented easily in a medical environment. In fact, scientists have already tested it on malignant breast cells treated with a standard drug, doxorubicin.

The EPFL team is currently in discussion with oncologists to continue jointly developing their procedure. Within a few months, researchers say, a startup company will likely be created to help bring the laboratory work into the hospital setting.

###

Researcher Contact:

Robert Meissner, EPFL
robert.meissner@epfl.ch
+ 41 216936752


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/epfd-trd030413.php

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Asia stocks fall amid US budget impasse

BANGKOK (AP) ? Uncertainty about the outcome of a budget battle among political leaders in Washington pushed Asian stock markets lower on Monday.

President Barack Obama and his political opponents have failed so far to agree on a way to roll back automatic spending cuts that took effect Friday. Those cuts slash $85 billion from the nation's budget, which could slow down the economy.

U.S. lawmakers say they want to undo the cuts so that federal programs can be spared but are divided over whether higher taxes should be used to pay for them.

Evan Lucas of IG Markets in Melbourne said he believes the budget fight is just "another political distraction that will cause some investors to cash out and buy back in on the dips."

Hong Kong's Hang Seng fell 1 percent to 22,646.46. South Korea's Kospi shed 0.3 percent to 2,019.64. Australia's S&P/ASX 200 lost 1.2 percent to 5,026.80.

Japan's Nikkei 225 index reached its highest intraday level since September 2008 before retreating slightly to 11,674.90, a gain of 0.6 percent.

Investors are seemingly in a buoyant mood ahead of a leadership change at the Bank of Japan. Gov. Masaaki Shirakawa will step down March 19, making way for a new chief who supports Prime Minister Shinzo Abe's call for bolder monetary easing. The central bank meets Wednesday and Thursday for a regular monetary policy review.

A positive manufacturing report pushed Wall Street higher on Friday. The Dow Jones industrial average rose 0.3 percent to close at 14,089.66. The Standard & Poor's 500 index rose 0.2 percent to 1,518.20. The Nasdaq composite gained 0.3 percent to 3,169.74.

U.S. manufacturing expanded in February at the fastest pace since June 2011. The Institute for Supply Management said that its index of factory activity rose in February to 54.2, up from January's reading of 53.1. A reading above 50 indicates expansion.

Benchmark oil for April delivery was down 7 cents to $90.61 per barrel in electronic trading on the New York Mercantile Exchange. The contract fell $1.37 to close at $90.68 a barrel on the Nymex on Friday.

In currencies, the euro fell to $1.3009 from $1.3017 late Friday in New York. The dollar fell to 93.32 yen from 93.58 yen.

Source: http://news.yahoo.com/asia-stocks-fall-amid-us-budget-impasse-031313450--finance.html

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